2019 novel Coronavirus: current knowledge, cardiovascular implications and management.
Minerva Cardiol Angiol
; 69(4): 377-388, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1431235
ABSTRACT
From first cases reported on December 31, 2019, in Wuhan, Hubei-China, SARS-CoV2 has spread worldwide and finally the World Health Organization declared the pandemic status. We summarize what makes SARS-CoV2 different from previous highly pathogenic coronaviruses and why it is so contagious, with focus on its clinical presentation and diagnosis, which is mandatory to start the appropriate management and reduce the transmission. As far as infection pathophysiology is still not completely clarified, this review focuses also on the cardiovascular (CV) implication of COVID-19 and the capability of this virus to cause direct myocardial injury, myocarditis and other CV manifestations. Furthermore, we highlight the relationship between the virus, enzyme ACE2 and ACE inhibitors. Clinical management involves the intensive care approach with intubation and mechanical ventilation in the most serious cases and drug therapy with several apparently promising old and new molecules. Aim of this review is then to summarize what is actually known about the SARS-CoV2 and its cardiovascular implications.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cardiovascular System
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Minerva Cardiol Angiol
Year:
2021
Document Type:
Article
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