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Effect of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on COVID-19 outcome: A Record Based Observational Study in West Bengal
The Journal of the Association of Physicians of India ; 69(7):11-12, 2021.
Article in English | Scopus | ID: covidwho-1431386
ABSTRACT

BACKGROUND:

Since its first identification in December 2019, in WUHAN (CHINA), SARS-COV-2, causative agent of Corona virus pandemic, has affected millions of people worldwide, causing thousands of death. There is much speculation about the interplay between ACEI/ARB and Corona virus infection, as for internalization into host cell SARS-COV-2 binds through S spike protein to ACE-2, aided TMPRSS2.

METHODS:

A record based observational study has been conducted (data obtained from the clinics of fourteen physicians) in two worst affected districts of West Bengal, to find out the association of ACEI/ARB on patients, suffering from Corona virus infection. The study-protocol has already been approved by Clinical Research Ethics Committee of Calcutta School of Tropical Medicine. (IEC Ref. No CREC-STM/2020-AS-37)

Results:

Increasing age, male sex and presence of co-morbidities (viz. Diabetes, COPD) are significantly associated with the occurrence of moderate and severe disease. Drugs (viz. ACEI/ARB), though are associated with less severe disease, have not achieved statistical significance, in the present study.

CONCLUSION:

Drugs, like ACEI/ARB, should be continued in patients suffering from COVID-19 infection, (if they are already on these drugs). © Journal of the Association of Physicians of India 2011.
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Collection: Databases of international organizations Database: Scopus Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: The Journal of the Association of Physicians of India Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: Scopus Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: The Journal of the Association of Physicians of India Year: 2021 Document Type: Article