Drug repositioning is an alternative for the treatment of coronavirus COVID-19.

Serafin, Marissa B; Bottega, Angelita; Foletto, Vitória S; da Rosa, Taciéli F; Hörner, Andreas; Hörner, Rosmari

Serafin, Marissa B; Bottega, Angelita; Foletto, Vitória S; da Rosa, Taciéli F; Hörner, Andreas; Hörner, Rosmari.

Serafin MB; Universidade Federal de Santa Maria, Programa de Pós-graduacão em Ciências Farmacêuticas, Santa Maria, RS, Brasil.
Bottega A; Universidade Federal de Santa Maria, Programa de Pós-graduacão em Ciências Farmacêuticas, Santa Maria, RS, Brasil.
Foletto VS; Universidade Federal de Santa Maria, Programa de Pós-graduacão em Ciências Farmacêuticas, Santa Maria, RS, Brasil.
da Rosa TF; Universidade Federal de Santa Maria, Programa de Pós-graduacão em Ciências Farmacêuticas, Santa Maria, RS, Brasil.
Hörner A; Universidade Federal de Santa Maria, Pós-Graduação Mestrado Profissional em Ciências da Saúde.
Hörner R; Universidade Federal de Santa Maria, Programa de Pós-graduacão em Ciências Farmacêuticas, Santa Maria, RS, Brasil; Universidade Federal de Santa Maria, Departamento de Análises Clínicas e Toxicológicas, Santa Maria, RS, Brasil. Electronic address: rosmari.ufsm@gmail.com.

Int J Antimicrob Agents ; 55(6): 105969, 2020 Jun.

Article in English | MEDLINE | ID: covidwho-143205

ABSTRACT

ABSTRACT

Given the extreme importance of the current pandemic caused by COVID-19, and as scientists agree there is no identified pharmacological treatment, where possible, therapeutic alternatives are raised through drug repositioning. This paper presents a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-CoV, with the potential for use in the treatment of COVID-19 disease.

Subject(s)

Antiviral Agents/therapeutic use; Betacoronavirus/drug effects; Coronavirus Infections/drug therapy; Drug Repositioning/methods; Pneumonia, Viral/drug therapy; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/therapeutic use; Alanine/analogs & derivatives; Alanine/therapeutic use; COVID-19; Chloroquine/therapeutic use; Humans; Hydroxychloroquine/therapeutic use; Pandemics; SARS-CoV-2; Teicoplanin/therapeutic use; COVID-19 Drug Treatment

Keywords

COVID-19; Repositioning; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Drug Repositioning / Betacoronavirus Limits: Humans Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article Affiliation country: J.ijantimicag.2020.105969

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