Outcomes of atrial fibrillation in patients with COVID-19 pneumonia: A systematic review and meta-analysis.
Am J Emerg Med
; 50: 661-669, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1432721
ABSTRACT
BACKGROUND:
Recently, emerging evidence has suggested that atrial fibrillation (AF) has an epidemiological correlation with coronavirus disease 2019 (COVID-19). However, the clinical outcomes of AF in COVID-19 remain inconsistent and inconclusive. The aim of this study was to provide a comprehensive description of the impact of AF on the prognosis of patients with COVID-19 pneumonia.METHODS:
Three electronic databases (PubMed, Embase, and Web of Science) were searched for eligible studies as of March 1, 2021. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the associations between AF (preexisting and new-onset) and in-hospital mortality, post-discharge mortality, and ventilator use.RESULTS:
A total of 36 individual studies were incorporated into our meta-analysis. The combined results revealed that preexisting AF was associated with increased in-hospital mortality (pooled OR 2.07; 95% CI 1.60-2.67; p < 0.001), post-discharge mortality (pooled OR 2.69; 95% CI 1.24-5.83; p < 0.05), and ventilator utilization (pooled OR 4.53; 95% CI 1.33-15.38; p < 0.05) in patients with COVID-19. In addition, our data demonstrated that new-onset AF during severe acute respiratory syndrome coronavirus 2 infection was significantly correlated with increased mortality (pooled OR 2.38; 95% CI 2.04-2.77; p < 0.001).CONCLUSIONS:
The presence of AF is correlated with adverse outcomes in patients with COVID-19 pneumonia, which deserves increased attention and should be managed appropriately to prevent adverse outcomes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Atrial Fibrillation
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Am J Emerg Med
Year:
2021
Document Type:
Article
Affiliation country:
J.ajem.2021.09.050
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