Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury.
Crit Care Clin
; 37(4): 749-776, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1433017
ABSTRACT
The pathophysiology of acute respiratory distress syndrome (ARDS) is marked by inflammation-mediated disruptions in alveolar-capillary permeability, edema formation, reduced alveolar clearance and collapse/derecruitment, reduced compliance, increased pulmonary vascular resistance, and resulting gas exchange abnormalities due to shunting and ventilation-perfusion mismatch. Mechanical ventilation, especially in the setting of regional disease heterogeneity, can propagate ventilator-associated injury patterns including barotrauma/volutrauma and atelectrauma. Lung injury due to the novel coronavirus SARS-CoV-2 resembles other causes of ARDS, though its initial clinical characteristics may include more profound hypoxemia and loss of dyspnea perception with less radiologically-evident lung injury, a pattern not described previously in ARDS.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Lung Injury
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Crit Care Clin
Journal subject:
Critical Care
Year:
2021
Document Type:
Article
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