COVID-19-Associated Acute Respiratory Distress Syndrome: Lessons from Tissues and Cells.
Crit Care Clin
; 37(4): 777-793, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1433018
ABSTRACT
Reports examining lung histopathology in coronavirus disease 2019 (COVID-19) infection provide an essential body of information for clinicians and investigators. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced lung injury is complex, involving the airways, alveoli, and pulmonary vessels. Although no anatomic marker is specific, the signature histologic lesion is diffuse alveolar damage (DAD). The biological and molecular mechanisms that drive this pattern of injury are unknown, and the relationship of SARS-CoV-2-induced DAD to physiologic alterations and clinical outcomes in COVID-19-associated acute respiratory distress syndrome is undefined. Additional histologic patterns that may be variant phenotypes have been reported.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
COVID-19
Type of study:
Prognostic study
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Crit Care Clin
Journal subject:
Critical Care
Year:
2021
Document Type:
Article
Affiliation country:
J.ccc.2021.05.004
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