High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines.
Cell Rep
; 37(2): 109823, 2021 10 12.
Article
in English
| MEDLINE | ID: covidwho-1433047
ABSTRACT
Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case can differ. Here, we compare SARS-CoV-2 spike receptor binding domain (S1-RBD)-specific primary MBCs that form in response to infection or a single mRNA vaccination. Both primary MBC populations have similar frequencies in the blood and respond to a second S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A+ subset and secondary MBCs that are mostly IgG+ and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Plasma Cells
/
COVID-19 Vaccines
/
SARS-CoV-2
Type of study:
Randomized controlled trials
Topics:
Vaccines
/
Variants
Limits:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Cell Rep
Year:
2021
Document Type:
Article
Affiliation country:
J.celrep.2021.109823
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