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High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines.
Pape, Kathryn A; Dileepan, Thamotharampillai; Kabage, Amanda J; Kozysa, Daria; Batres, Rodolfo; Evert, Clayton; Matson, Michael; Lopez, Sharon; Krueger, Peter D; Graiziger, Carolyn; Vaughn, Byron P; Shmidt, Eugenia; Rhein, Joshua; Schacker, Timothy W; Khoruts, Alexander; Jenkins, Marc K.
  • Pape KA; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Dileepan T; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Kabage AJ; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Kozysa D; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Batres R; Department of Medicine, Division of Infectious Disease, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Evert C; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Matson M; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Lopez S; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Krueger PD; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Graiziger C; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Vaughn BP; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Shmidt E; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Rhein J; Department of Medicine, Division of Infectious Disease, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Schacker TW; Department of Medicine, Division of Infectious Disease, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Khoruts A; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Department of Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  • Jenkins MK; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: jenki002@umn.edu.
Cell Rep ; 37(2): 109823, 2021 10 12.
Article in English | MEDLINE | ID: covidwho-1433047
ABSTRACT
Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case can differ. Here, we compare SARS-CoV-2 spike receptor binding domain (S1-RBD)-specific primary MBCs that form in response to infection or a single mRNA vaccination. Both primary MBC populations have similar frequencies in the blood and respond to a second S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A+ subset and secondary MBCs that are mostly IgG+ and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Cells / COVID-19 Vaccines / SARS-CoV-2 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.109823

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Cells / COVID-19 Vaccines / SARS-CoV-2 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.109823