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NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems.
Bazrafkan, Mahshid; Hosseini, Elham; Nazari, Mahboobeh; Amorim, Christiani Andrade; Sadeghi, Mohammad Reza.
  • Bazrafkan M; Reproductive Biotechnology Research Center, Avicenna Research Institute (ARI), ACECR, Tehran, Iran.
  • Hosseini E; Department of Obstetrics and Gynecology, IVF Clinic, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: elhamhosseinid@gmail.com.
  • Nazari M; Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
  • Amorim CA; Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
  • Sadeghi MR; Reproductive Biotechnology Research Center, Avicenna Research Institute (ARI), ACECR, Tehran, Iran.
J Reprod Immunol ; 148: 103427, 2021 11.
Article in English | MEDLINE | ID: covidwho-1433587
ABSTRACT
To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / COVID-19 / Infertility Type of study: Observational study Topics: Long Covid Limits: Humans Language: English Journal: J Reprod Immunol Year: 2021 Document Type: Article Affiliation country: J.jri.2021.103427

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / COVID-19 / Infertility Type of study: Observational study Topics: Long Covid Limits: Humans Language: English Journal: J Reprod Immunol Year: 2021 Document Type: Article Affiliation country: J.jri.2021.103427