Your browser doesn't support javascript.
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study.
Sinaci, Selcan; Ocal, Doga Fatma; Yucel Yetiskin, Didem Fatma; Uyan Hendem, Derya; Buyuk, Gul Nihal; Goncu Ayhan, Sule; Tanacan, Atakan; Ozgu-Erdinc, A Seval; Moraloglu Tekin, Ozlem; Sahin, Dilek.
  • Sinaci S; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey. Electronic address: selcansinaci@gmail.com.
  • Ocal DF; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Yucel Yetiskin DF; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Uyan Hendem D; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Buyuk GN; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Goncu Ayhan S; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Tanacan A; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Ozgu-Erdinc AS; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Moraloglu Tekin O; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey; University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Sahin D; Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey; University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
J Steroid Biochem Mol Biol ; 213: 105964, 2021 10.
Article in English | MEDLINE | ID: covidwho-1433601
ABSTRACT

OBJECTIVE:

We aimed to evaluate the vitamin D status of pregnant women with COVID-19, and the association between vitamin D level and severity of COVID-19.

METHODS:

In this case control study, 159 women with a single pregnancy and tested positive for SARS-CoV-2, and randomly selected 332 healthy pregnant women with similar gestational ages were included. COVID-19 patients were classified as mild, moderate, and severe. Vitamin D deficiency was defined as 25-hydroxycholecalciferol <20 ng/mL (50 nmol/L), and 25-OH D vitamin <10 ng/mL was defined as severe vitamin D deficiency, also 25-OH D vitamin level between 20-29 ng/mL (525-725 nmol/L) was defined as vitamin D insufficiency.

RESULTS:

Vitamin D levels of the pregnant women in the COVID-19 group (12.46) were lower than the control group (18.76). 25-OH D vitamin levels of those in the mild COVID-19 category (13.69) were significantly higher than those in the moderate/severe category (9.06). In terms of taking vitamin D supplementation, there was no statistically significant difference between the groups. However, it was observed that all of those who had severe COVID-19 were the patients who did not take vitamin D supplementation.

CONCLUSION:

The vitamin D levels are low in pregnant women with COVID-19. Also, there is a significant difference regarding to vitamin D level and COVID-19 severity in pregnant women. Maintenance of adequate vitamin D level can be useful as an approach for the prevention of an aggressive course of the inflammation induced by this novel coronavirus in pregnant women.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Vitamin D / Vitamin D Deficiency / Dietary Supplements / Cytokine Release Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Adult / Female / Humans / Pregnancy Language: English Journal: J Steroid Biochem Mol Biol Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Vitamin D / Vitamin D Deficiency / Dietary Supplements / Cytokine Release Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Adult / Female / Humans / Pregnancy Language: English Journal: J Steroid Biochem Mol Biol Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article