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Inactivation of SARS-CoV-2 by Catechins from Green Tea.
Nishimura, Hidekazu; Okamoto, Michiko; Dapat, Isolde; Katsumi, Masanori; Oshitani, Hitoshi.
  • Nishimura H; Virus Research Center, Clinical Research Division, Sendai Medical Center, Japan.
  • Okamoto M; Department of Virology, Tohoku University Graduate School of Medicine, Japan.
  • Dapat I; Virus Research Center, Clinical Research Division, Sendai Medical Center, Japan.
  • Katsumi M; Sendai City Institute for Public Health, Japan.
  • Oshitani H; Department of Virology, Tohoku University Graduate School of Medicine, Japan.
Jpn J Infect Dis ; 74(5): 421-423, 2021 Sep 22.
Article in English | MEDLINE | ID: covidwho-1436359
Semantic information from SemMedBD (by NLM)
1. Cell Count USES Reagents
Subject
Cell Count
Predicate
USES
Object
Reagents
2. Cell Count USES Drug Delivery Systems
Subject
Cell Count
Predicate
USES
Object
Drug Delivery Systems
3. Reagents AFFECTS Virus Physiological Phenomena
Subject
Reagents
Predicate
AFFECTS
Object
Virus Physiological Phenomena
4. catechin DISRUPTS COVID-19
Subject
catechin
Predicate
DISRUPTS
Object
COVID-19
5. Cell Count USES Reagents
Subject
Cell Count
Predicate
USES
Object
Reagents
6. Cell Count USES Drug Delivery Systems
Subject
Cell Count
Predicate
USES
Object
Drug Delivery Systems
7. Reagents AFFECTS Virus Physiological Phenomena
Subject
Reagents
Predicate
AFFECTS
Object
Virus Physiological Phenomena
8. catechin DISRUPTS COVID-19
Subject
catechin
Predicate
DISRUPTS
Object
COVID-19
ABSTRACT
Green tea extracts effectively inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro in a dose-dependent manner. Ten-fold serially diluted solutions of catechin mixture reagent from green tea were mixed with the viral culture fluid at a volume ratio of 91, respectively, and incubated at room temperature for 5 min. The solution of 10 mg/mL catechin reagent reduced the viral titer by 4.2 log and 1.0 mg/mL solution by one log. Pre-infection treatment of cells with the reagent alone did not affect viral growth. In addition, cells treated with only the reagent were assayed for host cell viability using the WST-8 system, and almost no host cell damage by the treatment was observed. These findings suggested that the direct treatment of virus with the reagent before inoculation decreased the viral activity and that catechins might have the potential to suppress SARSCoV-2 infection.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Tea / Catechin / SARS-CoV-2 Subject: Antiviral Agents / Tea / Catechin / SARS-CoV-2 Language: English Journal: Jpn J Infect Dis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Tea / Catechin / SARS-CoV-2 Subject: Antiviral Agents / Tea / Catechin / SARS-CoV-2 Language: English Journal: Jpn J Infect Dis Year: 2021
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