Myocardial injury in COVID-19 patients is associated with the thickness of epicardial adipose tissue.
Kardiologiia
; 61(8): 48-53, 2021 Aug 31.
Article
in English
| MEDLINE | ID: covidwho-1436434
ABSTRACT
Aim High sensitive troponin (hs-TnI) levels may increase secondary to Coronavirus disease-2019 (COVID-19), and this increase is associated with cardiovascular mortality in COVID-19 patients. Epicardial adipose tissue (EAT) is associated with myocardial injury directly as a reservoir tissue for coronavirus, and indirectly through mediators it secretes as an apocrine gland. We aimed to evaluate the relationship between myocardial injury secondary to COVID-19 infection and EAT thickness.Material and methods Thoracic computed tomography (CT) was performed in 73 consecutive patients diagnosed with COVID-19. EAT thickness and volume were calculated by two radiologists blind to the study data. We formed two groups according to hs-TnI concentrations, patients with myocardial damage (hs-TnI ≥11.6ângâ/âl) and without myocardial damage (hs-TnI<11.6 ngâ/âdl).Results A total of 46 patients were women (63.0â%). The mean age was 66.4±12.3 yrs in the myocardial injury group and 55.9±9.7 yrs in the group without myocardial injury (p<0.001). There were 20 hypertensive patients (68.9â%) in the injury group, while there were 12 hypertensive patients (27.3â%) in the group without injury (p=0.001). Glucose, C-reactive protein, D-dimer, white blood cell count, neutrophil, and neutrophilâ/âlymphocyte ratio were higher in the injury group (p<0.05, for all variables). The mean EAT thickness was 5.6±1.6 mm in the injury group, whereas it was 4.8±1.8 mm in the group without injury (p=0.031). EAT thickness of 4.85 mm and above was associated with the myocardial injury with 65â% sensitivity and 39â% specificity (AUC=0.65, 95â% CI 0.52-078, p=0.031).Conclusion In patients with COVID-19 infection, higher rates of myocardial injury were observed as the EAT thickness increased. Epicardial adipose tissue, contributes to cytokine-mediated myocardial injury either directly or indirectly by acting as a reservoir for coronavirus. Increased EAT thickness is associated with myocardial injury in COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
English
Journal:
Kardiologiia
Year:
2021
Document Type:
Article
Affiliation country:
Cardio.2021.8.n1638
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