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Comparison of severe and critical COVID-19 patients imported from Russia with and without influenza A infection in Heilongjiang Province: a retrospective study.
Dai, Qingqing; Ye, Ming; Tang, Zhiqiang; Yu, Kaijiang; Gao, Yang; Yang, Zhenyu; Zheng, Junbo; Zuo, Shu; Liu, Yan; Xie, Fengjie; Han, Qiuyuan; He, Hua; Wang, Hongliang.
  • Dai Q; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Ye M; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Tang Z; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yu K; Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Gao Y; Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yang Z; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zheng J; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zuo S; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Liu Y; Department of Medical Statistics, Harbin Medical University, Harbin, China.
  • Xie F; Department of Critical Care Medicine, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.
  • Han Q; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • He H; Department of Infectious Disease, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.
  • Wang H; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ann Transl Med ; 9(18): 1446, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1436465
ABSTRACT

BACKGROUND:

The rapid spread of coronavirus disease-19 (COVID-19) poses a global health emergency, and cases entering China from Russia are quite diverse. This study explored and compared the clinical characteristics and outcomes of severe and critically ill COVID-19 patients from Russia with and without influenza A infection, treated in a northern Chinese hospital (Russia imported patients).

METHODS:

A total of 32 severe and critically ill Russia-imported COVID-19 patients treated in the Heilongjiang Imported Severe and Critical COVID-19 Treatment Center from April 6 to May 11, 2020 were included, including 8 cases (group A) with and 24 cases (group B) without influenza A infection. The clinical characteristics of each group were compared, including prolonged hospital stay, duration of oxygen therapy, time from onset to a negative SARS-CoV-2 qRT-PCR RNA (Tneg) result, and duration of bacterial infection.

RESULTS:

The results showed that blood group, PaO2/FiO2, prothrombin time (PT), prothrombin activity (PTA), computed tomography (CT) score, hospital stay, duration of oxygenation therapy, Tneg, and duration of bacterial infection were statistically different between the two groups (P<0.05). Multivariant regression analysis showed that the Sequential Organ Failure Assessment (SOFA) score, C-reactive protein (CRP), and influenza A infection were factors influencing hospital stay; SOFA score, CRP, and CT score were factors influencing the duration of oxygenation therapy; PaO2/FiO2, platelet count (PLT), and CRP were factors influencing Tneg; and gender, SOFA score, and influenza A infection were factors influencing the duration of bacterial infection.

CONCLUSIONS:

Influenza A infection is common in Russia-imported COVID-19 patients, which can prolong the hospital stay and duration of bacterial infection. Routinely screening and treating influenza A should be conducted early in such patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials Language: English Journal: Ann Transl Med Year: 2021 Document Type: Article Affiliation country: Atm-21-3912

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials Language: English Journal: Ann Transl Med Year: 2021 Document Type: Article Affiliation country: Atm-21-3912