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Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China.
Zhang, J; Wang, X; Jia, X; Li, J; Hu, K; Chen, G; Wei, J; Gong, Z; Zhou, C; Yu, H; Yu, M; Lei, H; Cheng, F; Zhang, B; Xu, Y; Wang, G; Dong, W.
  • Zhang J; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
  • Wang X; Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Jia X; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
  • Li J; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
  • Hu K; Department of Respirology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Chen G; Department of Respirology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Wei J; Department of Emergency, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Gong Z; Department of Infectious Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Zhou C; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Yu H; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
  • Yu M; Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Lei H; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Cheng F; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Zhang B; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
  • Xu Y; Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Electronic address: xy37138@163.com.
  • Wang G; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. Electronic address: wgh6402@163.com.
  • Dong W; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China. Electronic address: dwg@whu.edu.cn.
Clin Microbiol Infect ; 26(6): 767-772, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-143671
ABSTRACT

OBJECTIVE:

In December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear and our objective is to throw some light on these.

METHODS:

All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020, were enrolled in this retrospective cohort study.

RESULTS:

A total of 663 COVID-19 patients were included in this study. Among these, 247 (37.3%) had at least one kind of chronic disease; 0.5% of the patients (n = 3) were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical conditions, respectively. In our hospital, during follow-up 251 of 663 patients (37.9%) improved and 25 patients died, a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have a severe to critical COVID-19 condition, to show unimprovement, and to die (p <0.001, <0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95%CI 0.311-0.758; p 0.001), having a severe COVID-19 condition (OR = 0.129, 95%CI 0.082-0.201; p <0.001), expectoration (OR = 1.796, 95%CI 1.062-3.036; p 0.029), muscle ache (OR = 0.309, 95%CI 0.153-0.626; p 0.001), and decreased albumin (OR = 1.929, 95%CI 1.199-3.104; p 0.007) as being associated with unimprovement in COVID-19 patients.

CONCLUSION:

Male sex, a severe COVID-19 condition, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Disease Progression / Patient Acuity Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: J.cmi.2020.04.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Disease Progression / Patient Acuity Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: J.cmi.2020.04.012