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SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10.
Gomes, André M C; Farias, Guilherme B; Dias-Silva, Manuel; Laia, Joel; Trombetta, Amelia C; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F; Conceição, Carolina M; Costa-Reis, Renato; Adão-Serrano, Maria; Mota, Catarina; Almeida, Afonso R M; Sousa, Ana E; Fernandes, Susana M.
  • Gomes AMC; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Farias GB; Clínica Universitária de Medicina Intensiva, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Dias-Silva M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Laia J; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Trombetta AC; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Godinho-Santos A; Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Lisboa, 1749-016, Portugal.
  • Rosmaninho P; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Santos DF; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Conceição CM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Costa-Reis R; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Adão-Serrano M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Mota C; Serviço de Medicina Intensiva, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.
  • Almeida ARM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
  • Sousa AE; Serviço de Medicina Intensiva, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.
  • Fernandes SM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Eur J Immunol ; 51(12): 3194-3201, 2021 12.
Article in English | MEDLINE | ID: covidwho-1437042
ABSTRACT
Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Biomarkers / Receptors, CCR10 / SARS-CoV-2 / COVID-19 / Lung Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202149311

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Biomarkers / Receptors, CCR10 / SARS-CoV-2 / COVID-19 / Lung Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202149311