From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 PandemicâAssociated Pernio.
J Invest Dermatol
; 141(12): 2791-2796, 2021 12.
Article
in English
| MEDLINE | ID: covidwho-1437509
ABSTRACT
Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chilblains
/
SARS-CoV-2
/
COVID-19
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
J Invest Dermatol
Year:
2021
Document Type:
Article
Affiliation country:
J.jid.2021.05.024
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