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Titers of SARS CoV-2 antibodies in cord blood of neonates whose mothers contracted SARS CoV-2 (COVID-19) during pregnancy and in those whose mothers were vaccinated with mRNA to SARS CoV-2 during pregnancy.
Kashani-Ligumsky, Lior; Lopian, Miriam; Cohen, Ronnie; Senderovich, Hila; Czeiger, Shelly; Halperin, Ariel; Chaim, Adina Bar; Kremer, Irit; Lessing, Joseph B; Somekh, Eli; Neiger, Ran.
  • Kashani-Ligumsky L; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel. liorkashani@yahoo.com.
  • Lopian M; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. liorkashani@yahoo.com.
  • Cohen R; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel.
  • Senderovich H; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Czeiger S; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel.
  • Halperin A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Chaim AB; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel.
  • Kremer I; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Lessing JB; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel.
  • Somekh E; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Neiger R; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Perinatol ; 41(11): 2621-2624, 2021 11.
Article in English | MEDLINE | ID: covidwho-1437659
ABSTRACT

OBJECTIVE:

We compared neonatal immunity after vaccination against SARS-CoV-2 during pregnancy to that achieved after maternal infection. STUDY

DESIGN:

We tested cord blood from women infected with SARS-CoV-2 during pregnancy (group 1, n = 29), women who were vaccinated during pregnancy (group 2, n = 29) and from women not infected and not vaccinated (Group 3, n = 21) for titers of antibodies to both SARS-CoV-2 spike and 'N' proteins.

RESULTS:

Seventy-nine women were included Antibodies against SARS-CoV-2 spike protein were detected in all samples from Group 1 and 2. Antibodies to the 'N' protein were detected in 25/29 samples in Group 1. None of the samples from Group 3 had antibodies to either protein. Mean titers of SARS-CoV-2 antibodies were significantly higher in Group 2 than in Group 1 (p < 0.05).

CONCLUSIONS:

Neonates born to mothers vaccinated during pregnancy have higher antibody titers and may therefore have more prolonged protection than those born to women infected during pregnancy.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Perinatol Journal subject: Perinatology Year: 2021 Document Type: Article Affiliation country: S41372-021-01216-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Perinatol Journal subject: Perinatology Year: 2021 Document Type: Article Affiliation country: S41372-021-01216-1