Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (-) patients.
Pathog Glob Health
; 116(3): 178-184, 2022 05.
Article
in English
| MEDLINE | ID: covidwho-1437790
ABSTRACT
For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed with COVID-19 between April-June 2020 who were admitted to a university hospital, and 100 healthy controls were included. In the first statistical analysis performed between PCR-positive, CT-negative and PCR-negative, CT-positive patients; the AB of MBL2 genotype was significantly higher in the first group (p = 0.049). The B allele was also significantly higher in the same subgroup (p = 0.001). The absence of the AB genotype was found to increase the risk of CT positivity by 6.9 times. The AB genotype of MBL2 was higher in healthy controls (p = 0.006). The absence of the AB genotype was found to increase the risk of CT positivity; also, it can be used for early detection and isolation of patients with typical lung involvement who had enough viral loads, but whose initial PCR results were negative.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mannose-Binding Lectin
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Pathog Glob Health
Year:
2022
Document Type:
Article
Affiliation country:
20477724.2021.1984726
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