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Case report of restless anal syndrome as restless legs syndrome variant after COVID-19.
Nakamura, Itaru; Itoi, Takao; Inoue, Takeshi.
  • Nakamura I; Tokyo Medical University Hospital, Tokyo, Japan. task300@tokyo-med.ac.jp.
  • Itoi T; Department of Infection Prevention and Control, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. task300@tokyo-med.ac.jp.
  • Inoue T; Tokyo Medical University Hospital, Tokyo, Japan.
BMC Infect Dis ; 21(1): 993, 2021 Sep 23.
Article in English | MEDLINE | ID: covidwho-1438260
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) has a broad spectrum from respiratory and nasopharyngeal symptoms, cerebrovascular diseases, impaired consciousness, and skeletal muscle injury. Emerging evidence has indicated the neural spread of this novel coronavirus. Restless legs syndrome (RLS) is a common neurological, sensorimotor disorder, but highly under diagnosis disorder. Restless anal syndrome as restless legs syndrome variant associated with COVID-19 has been previously not published. We report a case presenting with restless anal syndrome following COVID-19. CASE PRESENTATION Although a 77-year-old male with COVID-19 improved to normal respiratory function 21 days after admission and treatment of favipiravir 200 mg per day for 14 days and dexamethasone 6.6 mg per day for 5 days, the insomnia and anxiety symptoms remained. Several weeks after discharge, he gradually began to experience restless, deep anal discomfort, approximately 10 cm from the perineal region. The following features were observed in the anal region; urge to move is essential, with worsening with rest, improvement with exercise, and worsening at evening. Colonoscopy revealed internal haemorrhoids without other rectal lesions. Neurological findings including deep tendon reflex, perineum loss of sensory and spinal cord injury, revealed no abnormalities. Diabetes militias, kidney dysfunction and iron deficiency status were not confirmed. Family history of RLS and periodic limb movements were not observed. Clonazepam at 1.5 mg per day resulted in the alleviation restless anal discomfort.

CONCLUSIONS:

We reported a case presenting with restless anal syndrome following affection of COVID-19 as restless legs syndrome variant. This case fulfilled 4 essential features of RLS, urge to move, worsening with rest, improvement with exercise, and worsening at evening. To date, no case of restless anal syndrome associated with COVID-19 has been previously published. This case report may reflect the associative impacts of COVID-19 on the neuropsychiatric state. The long-term outcomes of neuropsychiatric conditions should continue to be monitored.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Restless Legs Syndrome / Spinal Cord Injuries / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Variants Limits: Aged / Humans / Male Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06683-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Restless Legs Syndrome / Spinal Cord Injuries / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Variants Limits: Aged / Humans / Male Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06683-7