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The syndrome of inappropriate antidiuresis after vaccination against COVID-19: case report.
Lindner, Gregor; Ryser, Basil.
  • Lindner G; Department of Internal and Emergency Medicine, Buergerspital Solothurn, Schoengruenstrasse 42, 4500, Solothurn, Switzerland.
  • Ryser B; Department of Internal and Emergency Medicine, Buergerspital Solothurn, Schoengruenstrasse 42, 4500, Solothurn, Switzerland. basil.ryser@icloud.com.
BMC Infect Dis ; 21(1): 1000, 2021 Sep 25.
Article in English | MEDLINE | ID: covidwho-1438261
ABSTRACT

BACKGROUND:

The Syndrome of Inappropriate Antidiuresis (SIADH) has been described to be associated with a multitude of conditions and medications, including the severe acute respiratory syndrome coronavirus 2. We describe the case of a patient with newly diagnosed and symptomatic SIADH after receiving the second COVID-19 vaccination not explained otherwise. CASE PRESENTATION A 79-year-old male person was admitted to the emergency department due to a worsening of his general health state expressed by weakness, fatigue and anorexia. Vital signs and clinical findings were normal, in particular the patient was considered to be euvolemic. Laboratory investigations revealed a serum sodium of 117 mmol/L, a serum osmolality of 241 mosm/kg and a urea of 1.2 mmol/L with creatinine within normal range. Urine chemistry showed a urine osmolality of 412 mosm/kg and urine sodium of 110 mmol/L. TSH, C-reactive protein, and basal cortisol levels were normal. Under therapy with balanced crystalloid fluids, hyponatremia worsened and in absence of diuretic medications, diagnosis of SIADH was made. Since fluid restriction was not sufficiently effective, oral urea was administered. Under this therapy regimen hyponatremia resolved.

CONCLUSIONS:

Local as well as systemic reactions have been described for the new mRNA-based vaccines including pain and fever. Therefore, it is imaginable that the vaccine might trigger SIADH in some patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hyponatremia / Inappropriate ADH Syndrome Type of study: Case report / Prognostic study Topics: Vaccines Limits: Aged / Humans / Male Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06690-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hyponatremia / Inappropriate ADH Syndrome Type of study: Case report / Prognostic study Topics: Vaccines Limits: Aged / Humans / Male Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06690-8