Performance of existing and novel surveillance case definitions for COVID-19 in household contacts of PCR-confirmed COVID-19.
BMC Public Health
; 21(1): 1747, 2021 09 25.
Article
in English
| MEDLINE | ID: covidwho-1438266
ABSTRACT
BACKGROUND:
Optimized symptom-based COVID-19 case definitions that guide public health surveillance and individual patient management in the community may assist pandemic control.METHODS:
We assessed diagnostic performance of existing cases definitions (e.g. influenza-like illness, COVID-like illness) using symptoms reported from 185 household contacts to a PCR-confirmed case of COVID-19 in Wisconsin and Utah, United States. We stratified analyses between adults and children. We also constructed novel case definitions for comparison.RESULTS:
Existing COVID-19 case definitions generally showed high sensitivity (86-96%) but low positive predictive value (PPV) (36-49%; F-1 score 52-63) in this community cohort. Top performing novel symptom combinations included taste or smell dysfunction and improved the balance of sensitivity and PPV (F-1 score 78-80). Performance indicators were generally lower for children (< 18 years of age).CONCLUSIONS:
Existing COVID-19 case definitions appropriately screened in household contacts with COVID-19. Novel symptom combinations incorporating taste or smell dysfunction as a primary component improved accuracy. Case definitions tailored for children versus adults should be further explored.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
BMC Public Health
Journal subject:
Public Health
Year:
2021
Document Type:
Article
Affiliation country:
S12889-021-11683-y
Similar
MEDLINE
...
LILACS
LIS