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Hyperlipidemia and Obesity's Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection.
Khatchadourian, Christopher; Sisliyan, Christina; Nguyen, Kevin; Poladian, Nicole; Tian, Qi; Tamjidi, Faraaz; Luong, Bao; Singh, Manpreet; Robison, Jeremiah; Venketaraman, Vishwanath.
  • Khatchadourian C; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Sisliyan C; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Nguyen K; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Poladian N; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Tian Q; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Tamjidi F; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Luong B; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
  • Singh M; Department of Emergency Medicine, St. Barnabas Hospital Health System, Bronx, NY 10457, USA.
  • Robison J; Department of Emergency Medicine, St. Barnabas Hospital Health System, Bronx, NY 10457, USA.
  • Venketaraman V; College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Clin Pract ; 11(4): 694-707, 2021 Sep 22.
Article in English | MEDLINE | ID: covidwho-1438533
ABSTRACT
Obesity and hyperlipidemia are known to be risk factors for various pathological disorders, including various forms of infectious respiratory disease, including the current Coronavirus outbreak termed Coronavirus Disease 19 (COVID-19). This review studies the effects of hyperlipidemia and obesity on enhancing the inflammatory response seen in COVID-19 and potential therapeutic pathways related to these processes. In order to better understand the underlying processes of cytokine and chemokine-induced inflammation, we must further investigate the immunomodulatory effects of agents such as Vitamin D and the reduced form of glutathione as adjunctive therapies for COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Clin Pract Year: 2021 Document Type: Article Affiliation country: Clinpract11040085

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Clin Pract Year: 2021 Document Type: Article Affiliation country: Clinpract11040085