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Designing Inclusive HPV Cancer Vaccines and Increasing Uptake among Native Americans-A Cultural Perspective Review.
Bordeaux, Skyler J; Baca, Anthony W; Begay, Rene L; Gachupin, Francine C; Caporaso, J Gregory; Herbst-Kralovetz, Melissa M; Lee, Naomi R.
  • Bordeaux SJ; Department of Health Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
  • Baca AW; Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
  • Begay RL; Centers for American Indian and Alaska Native Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Gachupin FC; Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ 85711, USA.
  • Caporaso JG; Center for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
  • Herbst-Kralovetz MM; Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
  • Lee NR; Department of Obstetrics and Gynecology, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Curr Oncol ; 28(5): 3705-3716, 2021 09 24.
Article in English | MEDLINE | ID: covidwho-1438539
ABSTRACT
Despite a global and nationwide decrease, Native Americans continue to experience high rates of cancer morbidity and mortality. Vaccination is one approach to decrease cancer incidence such as the case of cervical cancer. However, the availability of vaccines does not guarantee uptake, as evident in the Coronavirus 2019 pandemic. Therefore, as we consider current and future cancer vaccines, there are certain considerations to be mindful of to increase uptake among Native Americans such as the incidence of disease, social determinants of health, vaccine hesitancy, and historical exclusion in clinical trials. This paper primarily focuses on human papillomavirus (HPV) and potential vaccines for Native Americans. However, we also aim to inform researchers on factors that influence Native American choices surrounding vaccination and interventions including cancer therapies. We begin by providing an overview of the historical distrust and trauma Native Americans experience, both past and present. In addition, we offer guidance and considerations when engaging with sovereign Tribal Nations in vaccine development and clinical trials in order to increase trust and encourage vaccine uptake.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Uterine Cervical Neoplasms / Cancer Vaccines / Papillomavirus Infections / Papillomavirus Vaccines Subject: Uterine Cervical Neoplasms / Cancer Vaccines / Papillomavirus Infections / Papillomavirus Vaccines Type of study: Determinantes_sociais_saude Language: English Journal: Curr Oncol Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Uterine Cervical Neoplasms / Cancer Vaccines / Papillomavirus Infections / Papillomavirus Vaccines Subject: Uterine Cervical Neoplasms / Cancer Vaccines / Papillomavirus Infections / Papillomavirus Vaccines Type of study: Determinantes_sociais_saude Language: English Journal: Curr Oncol Year: 2021
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