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Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?
Hanssen, Jaap L J; Stienstra, Johan; Boers, Stefan A; Pothast, Cilia R; Zaaijer, Hans L; Tjon, Jennifer M; Heemskerk, Mirjam H M; Feltkamp, Mariet C W; Arend, Sandra M.
  • Hanssen JLJ; Department of Infectious Diseases, Leiden University Medical Center, C5-P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Stienstra J; Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Boers SA; Department of Medical Microbiology, Leiden University Medical Center, E4-P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Pothast CR; Department of Hematology, Leiden University Medical Center, C2-R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Zaaijer HL; Sanquin Blood Supply Foundation, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
  • Tjon JM; Department of Hematology, Leiden University Medical Center, C2-R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Heemskerk MHM; Department of Hematology, Leiden University Medical Center, C2-R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Feltkamp MCW; Department of Medical Microbiology, Leiden University Medical Center, E4-P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
  • Arend SM; Department of Infectious Diseases, Leiden University Medical Center, C5-P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Infect Dis Rep ; 13(4): 855-864, 2021 Sep 27.
Article in English | MEDLINE | ID: covidwho-1438581
ABSTRACT
It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID-19 provided insight in the immunological responses after treatment with COVID-19 convalescent plasma (CCP). Treatment consisted of oxygen, repeated glucocorticosteroids and multiple dosages of CCP guided by antibody levels. Retrospectively performed humoral and cellular immunity analysis made clear that not every serological test for COVID-19 is appropriate for follow-up of sufficient neutralizing antibodies after CCP. In retrospect, we think that CCP merely bought time for this patient to develop an adequate cellular immune response which led to viral clearance and ultimately clinical recovery.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: Idr13040077

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: Idr13040077