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Vaccination for Respiratory Infections in Patients with Heart Failure.
Girerd, Nicolas; Chapet, Nicolas; Roubille, Camille; Roncalli, Jérôme; Salvat, Muriel; Mouquet, Frédéric; Lamblin, Nicolas; Gueffet, Jean-Pierre; Damy, Thibaud; Galinier, Michel; Tartiere, Jean-Michel; Janssen, Cécile; Berthelot, Emmanuelle; Aguilhon, Sylvain; Escamilla, Roger; Roubille, François.
  • Girerd N; Centre d'Investigations Cliniques-INSERM CHRU de Nancy, Institut Lorrain du Cœur et des Vaisseaux Louis Mathieu, Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France.
  • Chapet N; Department of Clinical Pharmacy, CHU de Montpellier, 34295 Montpellier, France.
  • Roubille C; Department of Internal Medicine, CHU Montpellier, Montpellier University, PhyMedExp, 34295 Montpellier, France.
  • Roncalli J; Service de Cardiologie, CHU de Toulouse-Rangueil, Université Paul Sabatier-Toulouse III, 31400 Toulouse, France.
  • Salvat M; CHU Grenoble Alpes, 38700 La Tronche, France.
  • Mouquet F; Department of Cardiology, Hôpital Privé Le Bois, 59000 Lille, France.
  • Lamblin N; Institut Pasteur, Université Lille, Inserm, CHU Lille, U1167 Lille, France.
  • Gueffet JP; Hôpital Privé du Confluent, 44000 Nantes, France.
  • Damy T; Referral Center for Cardiac Amyloidoisis, Department of Cardiology, GHU Henri Mondor-APHP, IMRB 955, 94000 Créteil, France.
  • Galinier M; Fédération des Services de Cardiologie, CHU Toulouse-Rangueil, Faculté de Médecine, Toulouse, Université Paul Sabatier-Toulouse III, 31400 Toulouse, France.
  • Tartiere JM; CHITS, Department of Cardiology, Hôpital Sainte-Musse, 83100 Toulon, France.
  • Janssen C; Centre Hospitalier Annecy Genevois, Infectious Diseases Unit, 74370 Annecy, France.
  • Berthelot E; Service de Cardiologie, Hôpital Bicêtre, AP-HP, University of Paris Sud, 94270 Le Kremlin-Bicêtre, France.
  • Aguilhon S; Cardiology Department, CHU de Montpellier, 34295 Montpellier, France.
  • Escamilla R; Service de Pneumologie, Hôpital Larrey, 31400 Toulouse, France.
  • Roubille F; Cardiology Department, INI-CRT, CHU de Montpellier, PhyMedExp, Université de Montpellier, INSERM, CNRS, 34295 Montpellier, France.
J Clin Med ; 10(19)2021 Sep 22.
Article in English | MEDLINE | ID: covidwho-1438635
ABSTRACT
Bronchopulmonary infections are a major trigger of cardiac decompensation and are frequently associated with hospitalizations in patients with heart failure (HF). Adverse cardiac effects associated with respiratory infections, more specifically Streptococcus pneumoniae and influenza infections, are the consequence of inflammatory processes and thrombotic events. For both influenza and pneumococcal vaccinations, large multicenter randomized clinical trials are needed to evaluate their efficacy in preventing cardiovascular events, especially in HF patients. No study to date has evaluated the protective effect of the COVID-19 vaccine in patients with HF. Different guidelines recommend annual influenza vaccination for patients with established cardiovascular disease and also recommend pneumococcal vaccination in patients with HF. The Heart Failure group of the French Society of Cardiology recently strongly recommended vaccination against COVID-19 in HF patients. Nevertheless, the implementation of vaccination recommendations against respiratory infections in HF patients remains suboptimal. This suggests that a national health policy is needed to improve vaccination coverage, involving not only the general practitioner, but also other health providers, such as cardiologists, nurses, and pharmacists. This review first summarizes the pathophysiology of the interrelationships between inflammation, infection, and HF. Then, we describe the current clinical knowledge concerning the protective effect of vaccines against respiratory diseases (influenza, pneumococcal infection, and COVID-19) in patients with HF and finally we propose how vaccination coverage could be improved in these patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194311

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194311