Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.
Eur Respir J
; 55(5)2020 05.
Article
in English
| MEDLINE | ID: covidwho-143997
ABSTRACT
Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40â
mL·cmH2O-1) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phenotype
/
Pneumonia, Viral
/
Coronavirus Infections
/
Severe acute respiratory syndrome-related coronavirus
/
Acute Lung Injury
/
Betacoronavirus
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Year:
2020
Document Type:
Article
Affiliation country:
13993003.01028-2020
Similar
MEDLINE
...
LILACS
LIS