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Immune imprinting and SARS-CoV-2 vaccine design.
Wheatley, Adam K; Fox, Annette; Tan, Hyon-Xhi; Juno, Jennifer A; Davenport, Miles P; Subbarao, Kanta; Kent, Stephen J.
  • Wheatley AK; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia.
  • Fox A; WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute, Melbourne, Australia.
  • Tan HX; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia.
  • Juno JA; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia.
  • Davenport MP; Kirby Institute, University of NSW, Sydney, Australia.
  • Subbarao K; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia; WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute, Melbourne, Australia.
  • Kent SJ; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia. Electronic address: skent@unimelb.edu.au.
Trends Immunol ; 42(11): 956-959, 2021 11.
Article in English | MEDLINE | ID: covidwho-1440136
ABSTRACT
Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.09.001

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.09.001