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The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases.
Cama, Viviana Falcón; Marín-Prida, Javier; Acosta-Rivero, Nelson; Acosta, Emilio F; Díaz, Leonardo Oramas; Casadesús, Ana V; Fernández-Marrero, Briandy; Gilva-Rodríguez, Nathalie; Cremata-García, Daina; Cervantes-Llanos, Majel; Piniella-Matamoros, Beatriz; Sánchez, Daisy; Del Rosario-Cruz, Leticia; Borrajero, Israel; Díaz, Angelina; González, Yorexis; Pentón-Arias, Eduardo; Montero-González, Teresita; Guillen-Nieto, Gerardo; Pentón-Rol, Giselle.
  • Cama VF; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: viviana.falcon@cigb.edu.cu.
  • Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Ave. 23 e/214 y 222, La Lisa, PO Box: 430, Havana, Cuba. Electronic address: javier.marin@ifal.uh.cu.
  • Acosta-Rivero N; Center of Protein Research, Department of Biochemistry, Faculty of Biology, University of Havana, Havana, Cuba. Electronic address: nelson.acosta@fbio.uh.cu.
  • Acosta EF; Center for Advanced Studies of Cuba, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: emilio.am@cea.cu.
  • Díaz LO; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: leonardo.oramas@cigb.edu.cu.
  • Casadesús AV; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: anav@cim.sld.cu.
  • Fernández-Marrero B; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: briandyf@cim.sld.cu.
  • Gilva-Rodríguez N; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: nathalie.gilva@cigb.edu.cu.
  • Cremata-García D; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: daina.cremata@cigb.edu.cu.
  • Cervantes-Llanos M; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: majel.cervantes@cigb.edu.cu.
  • Piniella-Matamoros B; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: beatriz.piniella@cigb.edu.cu.
  • Sánchez D; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: daisy.sg@cea.cu.
  • Del Rosario-Cruz L; Hospital Militar Central "Dr. Luis Díaz Soto", Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: lrosarioc@infomed.sld.cu.
  • Borrajero I; Hospital Clínico Quirúrgico "Hermanos Ameijeiras", Havana, Cuba. Electronic address: telepatol@hha.sld.cu.
  • Díaz A; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: angelina.dg@cea.cu.
  • González Y; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: yorexis.ga@cea.cu.
  • Pentón-Arias E; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: eduardo.penton@cigb.edu.cu.
  • Montero-González T; Hospital Militar Central "Dr. Luis Díaz Soto", Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: teremg@infomed.sld.cu.
  • Guillen-Nieto G; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: gerardo.guillen@cigb.edu.cu.
  • Pentón-Rol G; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: giselle.penton@cigb.edu.cu.
J Neuroimmunol ; 361: 577728, 2021 12 15.
Article in English | MEDLINE | ID: covidwho-1440213
ABSTRACT
We herein report, by using confocal immunofluorescence, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and microglia in three deceased COVID-19 cases, of between 78 and 85 years of age at death. The viral nucleocapsid was detected together with its ACE2 cell entry receptor, as well as the NLRP3 inflammasome in cerebral cortical tissues. It is noteworthy that NLRP3 was colocalized with CD68 + macrophages in the brain and lung of the deceased, suggesting the critical role of this type of inflammasome in SARS-CoV-2 lesions of the nervous system/lungs and supporting its potential role as a therapeutic target.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Microglia / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 Type of study: Case report Limits: Aged / Female / Humans / Male Language: English Journal: J Neuroimmunol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Microglia / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 Type of study: Case report Limits: Aged / Female / Humans / Male Language: English Journal: J Neuroimmunol Year: 2021 Document Type: Article