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Vaccinomics: a future avenue for vaccine development against emerging pathogens.
de la Fuente, José; Contreras, Marinela.
  • de la Fuente J; SaBio, Instituto De Investigación En Recursos Cinegéticos Irec-csic-uclm-jccm, Ciudad Real, Spain.
  • Contreras M; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.
Expert Rev Vaccines ; 20(12): 1561-1569, 2021 12.
Article in English | MEDLINE | ID: covidwho-1440547
ABSTRACT

INTRODUCTION:

Vaccines are a major achievement in medical sciences, but the development of more effective vaccines against infectious diseases is essential for prevention and control of emerging pathogens worldwide. The application of omics technologies has advanced vaccinology through the characterization of host-vector-pathogen molecular interactions and the identification of candidate protective antigens. However, major challenges such as host immunity, pathogen and environmental factors, vaccine efficacy and safety need to be addressed. Vaccinomics provides a platform to address these challenges and improve vaccine efficacy and safety. AREAS COVERED In this review, we summarize current information on vaccinomics and propose quantum vaccinomics approaches to further advance vaccine development through the identification and combination of antigen protective epitopes, the immunological quantum. The COVID-19 pandemic caused by SARS-CoV-2 is an example of emerging infectious diseases with global impact on human health. EXPERT OPINION Vaccines are required for the effective and environmentally sustainable intervention for the control of emerging infectious diseases worldwide. Recent advances in vaccinomics provide a platform to address challenges in improving vaccine efficacy and implementation. As proposed here, quantum vaccinomics will contribute to vaccine development, efficacy, and safety by facilitating antigen combinations to target pathogen infection and transmission in emerging infectious diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Communicable Diseases, Emerging / Vaccine Development Topics: Vaccines Limits: Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1987222

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Communicable Diseases, Emerging / Vaccine Development Topics: Vaccines Limits: Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1987222