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Delayed admissions and efficacy of steroid use in patients with critical and severe COVID-19: an apprehensive approach.
Akhtar, Hashaam; Khalid, Sundas; Rahman, Fazal-Ur-; Ali, Sabahat; Afridi, Maham; Khader, Yousef S; Hassan, Faheem; Akhtar, Nasim; Khan, Muhammad Mujeeb; Ikram, Aamer.
  • Akhtar H; Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental College, Islamabad 44000, Pakistan.
  • Khalid S; Department of Materials Engineering, School of Chemical and Materials Engineering, National University of Science and Technology, Islamabad 44000, Pakistan.
  • Rahman FU; Department of Medicine, Benazir Bhutto Hospital, Rawalpindi 44000, Pakistan.
  • Ali S; Department of Gynecology and Obstetrics, Pakistan Air Force Hospital, Islamabad 44000, Pakistan.
  • Afridi M; Department of Biotechnology, Quaid-i-Azam University, Islamabad 44000, Pakistan.
  • Khader YS; Department of Community Medicine, Public Health and Family Medicine/Faculty of Medicine, Jordan University of Science & Technology, Irbid 22110, Jordan.
  • Hassan F; CT Angio Department, Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC/NIHD),, Rawalpindi 44000, Pakistan.
  • Akhtar N; Department of General Medicine, Pakistan Institute of Medical Sciences, Islamabad 44000, Pakistan.
  • Khan MM; Department of Infectious Diseases, Rawalpindi Medical University, Rawalpindi 44000, Pakistan.
  • Ikram A; National Institute of Health, Islamabad 44000, Pakistan.
J Public Health (Oxf) ; 43(Suppl 3): iii43-iii48, 2021 12 08.
Article in English | MEDLINE | ID: covidwho-1440643
ABSTRACT

BACKGROUND:

Inadvertent delays in access to appropriate therapeutic interventions in high-risk group coronavirus disease 2019 (COVID-19) patients contribute to mortality in patients with severe/critical disease presentation.

OBJECTIVES:

The aim of this study was to determine the effect of timely admission to the hospital on mortality of patients with severe/critical COVID-19. Another secondary aspect of this study was to observe the efficacy of time-dependent use of corticosteroids on mortality of critical/severe COVID-19 patients.

METHODS:

Clinical data of 659 patients with severe/critical COVID-19, admitted to four major tertiary care hospitals from the Islamabad-Rawalpindi region of Pakistan was retrospectively collected from a period February-August 2020. Multivariate logistic regression analysis was carried out to determine the predictors of mortality in severe/critical COVID-19 patients.

RESULTS:

Out of a total of 659 patients, 469 (71.2%) patients died. Age > 60 years, presence of hypertension, heart disease and kidney disease along with late admission (>5 days) were significant predictors of mortality in patients with severe/critical COVID-19.

CONCLUSIONS:

The study highlights the importance of well-timed provision of appropriate medical interventions control COVID-19-associated mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Humans / Middle aged Language: English Journal: J Public Health (Oxf) Year: 2021 Document Type: Article Affiliation country: Pubmed

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Humans / Middle aged Language: English Journal: J Public Health (Oxf) Year: 2021 Document Type: Article Affiliation country: Pubmed