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COVID-19 in complex common variable immunodeficiency patients affected by lung diseases.
Milito, Cinzia; Soccodato, Valentina; Auria, Stefania; Pulvirenti, Federica; Quinti, Isabella.
  • Milito C; Department of Molecular Medicine, Sapienza University of Rome.
  • Soccodato V; Department of Molecular Medicine, Sapienza University of Rome.
  • Auria S; Department of Molecular Medicine, Sapienza University of Rome.
  • Pulvirenti F; Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, Rome, Italy.
  • Quinti I; Department of Molecular Medicine, Sapienza University of Rome.
Curr Opin Allergy Clin Immunol ; 21(6): 535-544, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-2161182
ABSTRACT
PURPOSE OF REVIEW In the general population, the risk of severe COVID-19 is associated with old age, male sex, hypertension, obesity and chronic diseases. Chronic lung diseases are listed as additional risk factors for hospitalization and ICU admission. The purpose of this review is to define whether chronic lung diseases, such as bronchiectasis and interstitial diseases, represent a risk for a severe SARS-CoV-2 infection in patients affected by common variable immunodeficiency (CVID), the most common symptomatic primary antibody defect. RECENT

FINDINGS:

CVID patients with SARS-CoV-2 infection have been reported since the beginning of the pandemic with a wide range of clinical presentations ranging from asymptomatic to mild/moderate and severe COVID-19. The meta-analysis of 88 CVID cases described in large cohorts and case reports demonstrated that CVID patients with chronic lung involvement have an increased risk for severe COVID-19 in comparison to CVID without lung diseases (50 vs. 28%, relative risk 1.75, 95% confidence interval 1.04--2.92, P = 0.043). Differently from the general population, age and metabolic comorbidities did not represent a risk factor for severe course in this patient's population.

SUMMARY:

Underlying chronic lung diseases but not age represent a risk factor for severe COVID-19 in CVID. Prompt therapeutic intervention should be adopted in SARS-CoV-2 positive CVID patients with chronic lung diseases independently of their age.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Bronchiectasis / Common Variable Immunodeficiency / Lung Diseases, Interstitial / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Curr Opin Allergy Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Bronchiectasis / Common Variable Immunodeficiency / Lung Diseases, Interstitial / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Curr Opin Allergy Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article