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[ANMCO Position paper: Use of sacubitril/valsartan in hospitalized patients with acute heart failure]. / Position paper ANMCO: Utilizzo di sacubitril/valsartan nel paziente ricoverato con scompenso cardiaco acuto.
Di Tano, Giuseppe; Di Lenarda, Andrea; Iacoviello, Massimo; Oliva, Fabrizio; Urbinati, Stefano; Aspromonte, Nadia; Cipriani, Manlio; Caldarola, Pasquale; Murrone, Adriano; Gulizia, Michele Massimo; Colivicchi, Furio; Gabrielli, Domenico.
  • Di Tano G; U.O. Cardiologia, Ospedale, ASST di Cremona, Cremona.
  • Di Lenarda A; S.C. Cardiovascolare e Medicina dello Sport, Azienda Sanitaria Universitaria Giuliano Isontina-ASUGI, Trieste.
  • Iacoviello M; S.C. Cardiologia, AOU Policlinico Riuniti di Foggia, Dipartimento delle Scienze Mediche e Chirurgiche, Università degli Studi, Foggia.
  • Oliva F; Cardiologia 1-Emodinamica, Unità di Cure Intensive Cardiologiche, Dipartimento Cardiotoracovascolare "A. De Gasperis", ASST Grande Ospedale Metropolitano Niguarda, Milano.
  • Urbinati S; U.O.C. Cardiologia, Ospedale Bellaria, AUSL di Bologna, Bologna.
  • Aspromonte N; U.O.S. Scompenso Cardiaco, Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma.
  • Cipriani M; Cardiologia 2-Insufficienza Cardiaca e Trapianti, Dipartimento Cardiotoracovascolare "A. De Gasperis", ASST Grande Ospedale Metropolitano Niguarda, Milano.
  • Caldarola P; U.O. Cardiologia-UTIC, Ospedale San Paolo, Bari.
  • Murrone A; S.C. Cardiologia-UTIC, Ospedali di Città di Castello e di Gubbio-Gualdo Tadino, AUSL Umbria 1, Perugia.
  • Gulizia MM; U.O.C. Cardiologia, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione "Garibaldi", Catania - Fondazione per il Tuo cuore - Heart Care Foundation, Firenze.
  • Colivicchi F; U.O.C. Cardiologia Clinica e Riabilitativa, Presidio Ospedaliero San Filippo Neri - ASL Roma 1, Roma.
  • Gabrielli D; U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliera San Camillo Forlanini, Roma.
G Ital Cardiol (Rome) ; 22(10): 854-860, 2021 Oct.
Article in Italian | MEDLINE | ID: covidwho-1441022
ABSTRACT
Sacubitril/valsartan (S/V) has been shown to reduce the risk of cardiovascular death or heart failure hospitalization and improve symptoms in chronic heart failure with reduced ejection fraction compared to enalapril. After 7 years since the publication of the results of PARADIGM-HF, further insight has been gained with potential new indications. Two prospective randomized multicenter studies (PIONEER-HF and TRANSITION) in patients hospitalized for acute heart failure (AHF) have shown an improved clinical outcome and biomarker profile as compared to enalapril, and good tolerability, safety and feasibility of initiating in-hospital administration of S/V. Furthermore, some studies have highlighted the favorable effects of S/V in attenuating adverse myocardial remodeling, supporting an early benefit after treatment. Observational data from non-randomized studies in AHF report that in-hospital and pre-discharge prescription of evidence-based drugs associated with better survival still remains suboptimal. Additionally, the COVID-19 pandemic has also negatively impacted on outpatient activities. Therefore, hospitalization, a real crossroads in the history of heart failure, must become a management and therapeutic opportunity for our patients. The objective of this ANMCO position paper is to encourage and facilitate early S/V administration in stabilized patients during hospitalization after an AHF episode, with the aim of improving care efficiency and clinical outcome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: Italian Journal: G Ital Cardiol (Rome) Journal subject: Cardiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: Italian Journal: G Ital Cardiol (Rome) Journal subject: Cardiology Year: 2021 Document Type: Article