No increase in anti-A isohemagglutinin titer after SARS-CoV-2 infection: A retrospective cohort analysis of group O apheresis platelet donors.
J Clin Apher
; 36(6): 882-885, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1441998
ABSTRACT
The risk of a hemolytic reaction during the transfusion of ABO non-identical PC is determined by the presence of natural anti-A IgM antibodies, the titer of which may increase after infections. The aim of the study was to evaluate the titer of anti-A isohemagglutinins in platelet concentrate (PC) obtained by apheresis from group O donors who experienced SARS-CoV-2 infection, and to compare the titer before and after infection. A retrospective single-center analysis of 21 PC donors with a previous COVID-19 history was performed. The results showed neither a statistically important increase in the anti-A IgM antibody titers nor a significant correlation between the anti-A IgM antibody level and anti-SARS-CoV-2S1 antibody titer in the donors with an asymptomatic or mild COVID-19. Further population-based studies on anti-A titers are necessary for a comprehensive assessment of this phenomenon.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Plateletpheresis
/
SARS-CoV-2
/
COVID-19
/
Hemagglutinins
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
/
Young adult
Language:
English
Journal:
J Clin Apher
Year:
2021
Document Type:
Article
Affiliation country:
Jca.21942
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