Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial.
Obesity (Silver Spring)
; 29(10): 1606-1614, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1442027
ABSTRACT
OBJECTIVE:
The aim of this study was to determine whether a Mediterranean-style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie-restricted, low-fat diet app in promoting weight loss.METHODS:
Participants (n = 155) with overweight/obesity (mean [SD] age 41 [11] years, BMI = 34 [5] kg/m2 , 71% female) were randomized to one of the interventions delivered entirely via app. Participants received a wireless scale and were instructed to take daily weight measurements. A third-party laboratory collected blood samples at baseline and 12 weeks.RESULTS:
Weight loss at 12 weeks was greater in the ketogenic (-5.6 kg; 95% CI -6.7 kg to -4.5 kg) compared with the low-fat group (-2.5 kg; 95% CI -3.6 kg to -1.4 kg) (between-group difference -3.1 kg; 95% CI -4.6 kg to -1.5 kg; p < 0.001). Weight loss at 24 weeks indicated durability of the effect (between-group difference -5.5 kg; 95% CI -8.3 kg to -2.8 kg; p < 0.001). Secondary/exploratory outcomes of hemoglobin A1c and liver enzymes were improved to a greater extent in the ketogenic diet group (p < 0.01).CONCLUSIONS:
Among adults with overweight/obesity, a ketogenic diet app with breath acetone biofeedback was superior to a calorie-restricted diet app at promoting weight loss in a real-world setting.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Overweight
/
Mobile Applications
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Obesity (Silver Spring)
Journal subject:
Nutritional Sciences
/
Physiology
/
Metabolism
Year:
2021
Document Type:
Article
Affiliation country:
Oby.23242
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