Your browser doesn't support javascript.
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity.
Butera, Yvan; Mukantwari, Enatha; Artesi, Maria; Umuringa, Jeanne d'arc; O'Toole, Áine Niamh; Hill, Verity; Rooke, Stefan; Hong, Samuel Leandro; Dellicour, Simon; Majyambere, Onesphore; Bontems, Sebastien; Boujemla, Bouchra; Quick, Josh; Resende, Paola Cristina; Loman, Nick; Umumararungu, Esperance; Kabanda, Alice; Murindahabi, Marylin Milumbu; Tuyisenge, Patrick; Gashegu, Misbah; Rwabihama, Jean Paul; Sindayiheba, Reuben; Gikic, Djordje; Souopgui, Jacob; Ndifon, Wilfred; Rutayisire, Robert; Gatare, Swaibu; Mpunga, Tharcisse; Ngamije, Daniel; Bours, Vincent; Rambaut, Andrew; Nsanzimana, Sabin; Baele, Guy; Durkin, Keith; Mutesa, Leon; Rujeni, Nadine.
  • Butera Y; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
  • Mukantwari E; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Artesi M; Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium.
  • Umuringa JD; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • O'Toole ÁN; Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium.
  • Hill V; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Rooke S; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland.
  • Hong SL; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland.
  • Dellicour S; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland.
  • Majyambere O; Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven, Leuven, Belgium.
  • Bontems S; Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven, Leuven, Belgium.
  • Boujemla B; Spatial Epidemiology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.
  • Quick J; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Resende PC; Department of Clinical Microbiology, University Hospital of Liège, Liège, Belgium.
  • Loman N; Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium.
  • Umumararungu E; University of Birmingham, Birmingham, England.
  • Kabanda A; University College London, London, England.
  • Murindahabi MM; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
  • Tuyisenge P; University of Birmingham, Birmingham, England.
  • Gashegu M; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Rwabihama JP; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Sindayiheba R; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Gikic D; School of Science, College of Science and Technology, University of Rwanda, Kigali, Rwanda.
  • Souopgui J; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Ndifon W; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Rutayisire R; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Gatare S; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Mpunga T; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Ngamije D; Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
  • Bours V; Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de, Bruxelles, Gosselies, Belgium.
  • Rambaut A; African Institute for Mathematical Sciences, Kigali, Rwanda.
  • Nsanzimana S; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Baele G; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Durkin K; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Mutesa L; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Rujeni N; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
Nat Commun ; 12(1): 5705, 2021 09 29.
Article in English | MEDLINE | ID: covidwho-1442779
ABSTRACT
COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, we report the detection of the first Rwandan cases of the B.1.1.7 and B.1.351 variants of concern among incoming travelers tested at Kigali International Airport. To assess the importance of viral introductions from neighboring countries and local transmission, we exploit available individual travel history metadata to inform spatio-temporal phylogeographic inference, enabling us to take into account infections from unsampled locations. We uncover an important role of neighboring countries in seeding introductions into Rwanda, including those from which no genomic sequences were available. Our results highlight the importance of systematic genomic surveillance and regional collaborations for a durable response towards combating COVID-19.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Travel-Related Illness / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Systematic review/Meta Analysis Topics: Variants Limits: Adult / Female / Humans / Male Country/Region as subject: Africa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25985-7

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Travel-Related Illness / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Systematic review/Meta Analysis Topics: Variants Limits: Adult / Female / Humans / Male Country/Region as subject: Africa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25985-7