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Retinal vessels modifications in acute and post-COVID-19.
Invernizzi, Alessandro; Schiuma, Marco; Parrulli, Salvatore; Torre, Alessandro; Zicarelli, Federico; Colombo, Valeria; Marini, Sara; Villella, Elena; Bertoni, Alice; Antinori, Spinello; Rizzardini, Giuliano; Galli, Massimo; Meroni, Luca; Giacomelli, Andrea; Staurenghi, Giovanni.
  • Invernizzi A; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy. alessandro.invernizzi@gmail.com.
  • Schiuma M; Department of Biomedical and Clinical Sciences "L. Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy. alessandro.invernizzi@gmail.com.
  • Parrulli S; The Discipline of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, Save Sight Institute, Sydney Eye Hospital, The University of Sydney, 8 Macquarie Street, Sydney, NSW, 2001, Australia. alessandro.invernizzi@gmail.com.
  • Torre A; Department of Biomedical and Clinical Sciences "L. Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
  • Zicarelli F; Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Colombo V; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
  • Marini S; Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Villella E; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
  • Bertoni A; Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Antinori S; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
  • Rizzardini G; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
  • Galli M; Eye Clinic, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
  • Meroni L; Department of Biomedical and Clinical Sciences "L. Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
  • Giacomelli A; Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Staurenghi G; Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy.
Sci Rep ; 11(1): 19373, 2021 09 29.
Article in English | MEDLINE | ID: covidwho-1442809
ABSTRACT
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 ± 10.9 to 92.2 ± 11.4 µm, p < 0.0001 and from 133.1 ± 19.3 to 124.6 ± 16.1 µm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Vessels / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-98873-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Vessels / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-98873-1