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COVID-19 vaccination in pregnant and lactating women: a systematic review.
Falsaperla, Raffaele; Leone, Guido; Familiari, Maria; Ruggieri, Martino.
  • Falsaperla R; Neonatal Intensive Care Unit, Auo Policlinico, 'Rodolico-san Marco' University of Catania, Italy.
  • Leone G; Acute End Emergency Pediatric Unit, Auo Policlinico 'Rodolico-san Marco' University of Catania, Italy.
  • Familiari M; Department of Clinical and Experimental Medicine, Auo Policlinico 'Rodolico-san Marco' University of Catania University of Catania, Italy.
  • Ruggieri M; Department of Clinical and Experimental Medicine, Auo Policlinico 'Rodolico-san Marco' University of Catania University of Catania, Italy.
Expert Rev Vaccines ; 20(12): 1619-1628, 2021 12.
Article in English | MEDLINE | ID: covidwho-1442947
ABSTRACT

INTRODUCTION:

The concern of undergoing vaccination during pregnancy and lactation, in absence of data on safety and efficacy in these target populations, is subject of ongoing debate nationally and internationally. However, the only real prophylactic strategy against COVID-19 is still mass vaccination, which means to vaccinate infants and pregnant and lactating women. AREAS COVERED This is a systematic review aiming to evaluate the safety and the efficacy of COVID-19 vaccines in pregnant and lactating women and their newborns. We did advanced research on PubMed and Google Scholar, and searched for any evidence also on ClinicalTrials.gov. Results refer to a timeline going until 12 June 2021. EXPERT OPINION Our efforts must be directed to vaccine more and more population groups which have been preliminarily excluded from the vaccination campaign. Studies have not so far highlighted plausible adverse effects in vaccinated pregnant women or in their newborns. Reactogenicity across lactating and pregnant women does not seem to differ from general population. Likewise, abortion rate does not differ from non-vaccinated pregnant women studied before the COVID-19 pandemic. It also seems that a major amount of anti-SARS-CoV-2 immunoglobulins is transferred through the placenta and the breastmilk to the newborn, providing humoral immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1986390

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: 14760584.2021.1986390