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ADEM after ChAdOx1 nCoV-19 vaccine: A case report.
Rinaldi, Virginia; Bellucci, Gianmarco; Romano, Andrea; Bozzao, Alessandro; Salvetti, Marco.
  • Rinaldi V; Neurology Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Bellucci G; Neurology Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Romano A; Neuroradiology Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Bozzao A; Neuroradiology Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Salvetti M; Neurology Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Mult Scler ; 28(7): 1151-1154, 2022 06.
Article in English | MEDLINE | ID: covidwho-1861988
ABSTRACT
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS), clinically defined by an acute polyfocal neurological syndrome usually with monophasic course. ADEM often occurs after infections, but 5%-10% of cases are preceded by vaccinations. Several cases of ADEM have been described after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, whereas no case has been reported after adenovirus-vectored or mRNA COVID-19 vaccine administration. Here we describe a case of ADEM presenting 2 weeks after receiving the first dose of ChAdOx1 nCoV-19 vaccine. Patient clinical/magnetic resonance imaging (MRI) status spontaneously improved and rapidly resolved with corticosteroids. A 4-month follow-up showed complete recovery and no relapses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Encephalomyelitis, Acute Disseminated / COVID-19 / ChAdOx1 nCoV-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Mult Scler Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: 13524585211040222

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Encephalomyelitis, Acute Disseminated / COVID-19 / ChAdOx1 nCoV-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Mult Scler Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: 13524585211040222