Your browser doesn't support javascript.
Prognostic Value of Leucocyte to High-Density Lipoprotein-Cholesterol Ratios in COVID-19 Patients and the Diabetes Subgroup.
Wang, Yuxiu; Zhang, Jiaoyue; Li, Huiqing; Kong, Wen; Zheng, Juan; Li, Yan; Wei, Qi; Li, Qin; Yang, Li; Xu, Ying; Li, Li; Wang, Hanyu; Sun, Hui; Xia, Wenfang; Liu, Geng; Zhong, Xueyu; Qiu, Kangli; Wang, Han; Liu, Hua; Song, Xiaoli; Xiong, Si; Liu, Yumei; Cui, Zhenhai; Chen, Lulu; Zeng, Tianshu.
  • Wang Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang J; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li H; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Kong W; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Zheng J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Y; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Wei Q; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Q; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Yang L; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu Y; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li L; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Wang H; Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.
  • Sun H; Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.
  • Xia W; Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.
  • Liu G; Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.
  • Zhong X; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Qiu K; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang H; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Liu H; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Song X; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Xiong S; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu Y; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Cui Z; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen L; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Zeng T; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne) ; 12: 727419, 2021.
Article in English | MEDLINE | ID: covidwho-1444039
ABSTRACT

Background:

Blood parameters, such as neutrophil-to-lymphocyte ratio, have been identified as reliable inflammatory markers with diagnostic and predictive value for the coronavirus disease 2019 (COVID-19). However, novel hematological parameters derived from high-density lipoprotein-cholesterol (HDL-C) have rarely been studied as indicators for the risk of poor outcomes in patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. Here, we aimed to assess the prognostic value of these novel biomarkers in COVID-19 patients and the diabetes subgroup.

Methods:

We conducted a multicenter retrospective cohort study involving all hospitalized patients with COVID-19 from January to March 2020 in five hospitals in Wuhan, China. Demographics, clinical and laboratory findings, and outcomes were recorded. Neutrophil to HDL-C ratio (NHR), monocyte to HDL-C ratio (MHR), lymphocyte to HDL-C ratio (LHR), and platelet to HDL-C ratio (PHR) were investigated and compared in both the overall population and the subgroup with diabetes. The associations between blood parameters at admission with primary composite end-point events (including mechanical ventilation, admission to the intensive care unit, or death) were analyzed using Cox proportional hazards regression models. Receiver operating characteristic curves were used to compare the utility of different blood parameters.

Results:

Of 440 patients with COVID-19, 67 (15.2%) were critically ill. On admission, HDL-C concentration was decreased while NHR was high in patients with critical compared with non-critical COVID-19, and were independently associated with poor outcome as continuous variables in the overall population (HR 0.213, 95% CI 0.090-0.507; HR 1.066, 95% CI 1.030-1.103, respectively) after adjusting for confounding factors. Additionally, when HDL-C and NHR were examined as categorical variables, the HRs and 95% CIs for tertile 3 vs. tertile 1 were 0.280 (0.128-0.612) and 4.458 (1.817-10.938), respectively. Similar results were observed in the diabetes subgroup. ROC curves showed that the NHR had good performance in predicting worse outcomes. The cutoff point of the NHR was 5.50. However, the data in our present study could not confirm the possible predictive effect of LHR, MHR, and PHR on COVID-19 severity.

Conclusion:

Lower HDL-C concentrations and higher NHR at admission were observed in patients with critical COVID-19 than in those with noncritical COVID-19, and were significantly associated with a poor prognosis in COVID-19 patients as well as in the diabetes subgroup.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Cholesterol, HDL Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.727419

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Cholesterol, HDL Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.727419