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Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course.
Kukla, Michal; Menzyk, Tomasz; Dembinski, Marcin; Winiarski, Marek; Garlicki, Aleksander; Bociaga-Jasik, Monika; Skonieczna, Magdalena; Hudy, Dorota; Maziarz, Barbara; Kusnierz-Cabala, Beata; Kapusta, Maria; Skladany, Lubomir; Grgurevic, Ivica; Mikolasevic, Ivana; Filipec-Kanizaj, Tajana; Wójcik-Bugajska, Malgorzata; Grodzicki, Tomasz; Rogula, Tomasz; Stygar, Dominika.
  • Kukla M; Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Menzyk T; Department of Endoscopy, University Hospital in Kraków, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Dembinski M; Department of Internal Medicine, Gastroenterology and Acute Intoxication, Regional Hospital, Lwowska 178A, 33-100 Tarnów, Poland.
  • Winiarski M; Department of Endoscopy, University Hospital in Kraków, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Garlicki A; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Bociaga-Jasik M; Department of Endoscopy, University Hospital in Kraków, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Skonieczna M; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Hudy D; Chair of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Maziarz B; Chair of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Kusnierz-Cabala B; Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland.
  • Kapusta M; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland.
  • Skladany L; Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland.
  • Grgurevic I; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland.
  • Mikolasevic I; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Filipec-Kanizaj T; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Wójcik-Bugajska M; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Kraków, Poland.
  • Grodzicki T; Department of Internal Medicine and HEGITO (Hepatology, Gastroenterology and Liver Transplantation), F.D. Roosevelt University Hospital, Nam. l. Svobodu 1, 975 17 Banska Bystrica, Slovakia.
  • Rogula T; School of Medicine, Zagreb University, Salata ul. 2, 10000 Zagreb, Croatia.
  • Stygar D; Division for Liver Diseases, Department of Gastroenterology, Dubrava University Hospital, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
Biomolecules ; 11(10)2021 09 28.
Article in English | MEDLINE | ID: covidwho-1444095
ABSTRACT
Analysis of liver biopsy specimens showed that SARS-CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers were enrolled in the study. Irisin, pentraxin 3, fetuin-A, and FGF-21 serum concentrations and biochemical parameters were assessed using an immunoenzymatic method with commercially available enzyme immunoassay (EIA) or enzyme-linked immunosorbent assay (ELISA) kits. Serum fetuin-A concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers. The serum concentration of FGF-21 was significantly increased in obese COVID-19 patients compared to overweight ones. Moreover, the FGF-21 level was higher in COVID-19 patients diagnosed with metabolic syndrome than in patients without metabolic syndrome. PTX3 concentration was higher in COVID-19 patients with higher HOMA-IR values than those with lower HOMA-IR values. COVID-19 patients with HOMA-IR ≤ 3 and >3 had significantly lower fetuin-A levels than the control group. Irisin concentration was significantly decreased in the HOMA-IR ≤ 3 COVID-19 subgroup when comparing with the control group. Lower levels of fetuin-A observed in COVID-19 patients despite higher HOMA-IR, CRP, and ferritin levels, pneumonia, patients requiring ICU care suggests that fetuin-A deficiency predisposes to more severe COVID-19 course. Upregulated pentraxin 3 may be used as a potential predictor of COVID-19 severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Alpha-2-HS-Glycoprotein / COVID-19 Type of study: Observational study Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: Biom11101422

Full text: Available Collection: International databases Database: MEDLINE Main subject: Alpha-2-HS-Glycoprotein / COVID-19 Type of study: Observational study Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: Biom11101422