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The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis.
Jayant, Kumar; Reccia, Isabella; Bachul, Piotr J; Al-Salmay, Yaser; Pyda, Jordan S; Podda, Mauro; Perez-Gutierrez, Angelica; Dor, Frank J M F; Becker, Yolanda; di Sabato, Diego; LaMattina, John; Barth, Rolf; Fung, John; Witkowski, Piotr.
  • Jayant K; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Reccia I; Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
  • Bachul PJ; Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
  • Al-Salmay Y; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Pyda JS; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Podda M; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Perez-Gutierrez A; Department of Emergency Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University Hospital Policlinico Duilio Casula, 09124 Cagliari, Italy.
  • Dor FJMF; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Becker Y; Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
  • di Sabato D; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • LaMattina J; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Barth R; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Fung J; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Witkowski P; Transplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
J Clin Med ; 10(19)2021 Sep 30.
Article in English | MEDLINE | ID: covidwho-1444247
ABSTRACT
Herein, we performed a meta-analysis of published clinical outcomes of corona virus disease 2019 (COVID-19) in hospitalized kidney transplant recipients. A systematic database search was conducted between December 1, 2019 and April 20, 2020. We analyzed 48 studies comprising 3137 kidney transplant recipients with COVID-19. Fever (77%), cough (65%), dyspnea (48%), and gastrointestinal symptoms (28%) were predominant on hospital admission. The most common comorbidities were hypertension (83%), diabetes mellitus (34%), and cardiac disease (23%). The pooled prevalence of acute respiratory distress syndrome and acute kidney injury were 58% and 48%, respectively. Invasive ventilation and dialysis were required in 24% and 22% patients, respectively. In-hospital mortality rate was as high as 21%, and increased to over 50% for patients in intensive care unit (ICU) or requiring invasive ventilation. Risk of mortality in patients with acute respiratory distress syndrome (ARDS), on mechanical ventilation, and ICU admission was increased OR = 19.59, OR = 3.80, and OR = 13.39, respectively. Mortality risk in the elderly was OR = 3.90; however, no such association was observed in terms of time since transplantation and gender. Fever, cough, dyspnea, and gastrointestinal symptoms were common on admission for COVID-19 in kidney transplant patients. Mortality was as high as 20% and increased to over 50% in patients in ICU and required invasive ventilation.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194533

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194533