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Inherited/Genetically-Associated Pheochromocytoma/ Paraganglioma Syndromes and COVID-19.
Ilias, Ioannis; Kaltsas, Gregory; Barkas, Konstantinos; Chrousos, George P.
  • Ilias I; Department of Endocrinology, Diabetes and Metabolism, "Elena Venizelou" Hospital, GR-11521 Athens, Greece.
  • Kaltsas G; 1st Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, GR-11527 Athens, Greece.
  • Barkas K; Department of Neurosurgery, "Agios Panteleimon" General Hospital of Nikaia-Pireas, GR-12351 Athens, Greece.
  • Chrousos GP; University Research Institute of Maternal and Child Health & Precision Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, GR-11527 Athens, Greece.
Medicina (Kaunas) ; 57(10)2021 Sep 28.
Article in English | MEDLINE | ID: covidwho-1444269
ABSTRACT
In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE). This would result in the stimulation of angiotensin (AT) II production and, hence, reduce the availability of ACE 2. The latter would provide decreased numbers of binding sites for the spike protein of SARS-CoV-2 and, therefore, result in less points of viral entry into cells. Thus, subjects with HIF1α-associated PPG syndromes may benefit from an inherent protective effect against COVID-19. Such an implication of HIF1α vis-à-vis COVID-19 could open ways of therapeutic interventions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Paraganglioma / Pheochromocytoma / Adrenal Gland Neoplasms / COVID-19 Limits: Humans Language: English Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Medicina57101033

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Paraganglioma / Pheochromocytoma / Adrenal Gland Neoplasms / COVID-19 Limits: Humans Language: English Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Medicina57101033