The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19.
Nutrients
; 13(10)2021 Sep 29.
Article
in English
| MEDLINE | ID: covidwho-1444284
ABSTRACT
There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising pharmacological targets. At the same time, nutritional modulation of immune system function has been proposed and is being investigated for the prevention of COVID-19 or as an adjunctive strategy combined with conventional therapy. Several studies indicate that several immunonutrients can regulate mast cell activity to reduce the de novo synthesis and/or release of histamine and other mediators that are considered to mediate, at least in part, the complex pathophysiology present in COVID-19. This review summarizes the effects on mast cell histamine of common immunonutrients that have been investigated for use in COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Signal Transduction
/
Histamine
/
COVID-19
/
Immune System
/
Mast Cells
/
Nutritional Physiological Phenomena
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Nu13103458
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