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Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates.
Jeon, Sungwon; Blazyte, Asta; Yoon, Changhan; Ryu, Hyojung; Jeon, Yeonsu; Bhak, Youngjune; Bolser, Dan; Manica, Andrea; Shin, Eun-Seok; Cho, Yun Sung; Kim, Byung Chul; Ryoo, Namhee; Choi, Hansol; Bhak, Jong.
  • Jeon S; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
  • Blazyte A; Department of Biomedical Engineering, College of Information and Biotechnology, UNIST, Ulsan 44919, Korea.
  • Yoon C; These authors contributed equally to this work.
  • Ryu H; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
  • Jeon Y; Department of Biomedical Engineering, College of Information and Biotechnology, UNIST, Ulsan 44919, Korea.
  • Bhak Y; These authors contributed equally to this work.
  • Bolser D; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
  • Manica A; Department of Biomedical Engineering, College of Information and Biotechnology, UNIST, Ulsan 44919, Korea.
  • Shin ES; These authors contributed equally to this work.
  • Cho YS; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
  • Kim BC; Department of Biomedical Engineering, College of Information and Biotechnology, UNIST, Ulsan 44919, Korea.
  • Ryoo N; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
  • Choi H; Department of Biomedical Engineering, College of Information and Biotechnology, UNIST, Ulsan 44919, Korea.
  • Bhak J; Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
Mol Cells ; 44(9): 680-687, 2021 Sep 30.
Article in English | MEDLINE | ID: covidwho-1444539
ABSTRACT
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / COVID-19 Type of study: Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Mol Cells Journal subject: Molecular Biology Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / COVID-19 Type of study: Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Mol Cells Journal subject: Molecular Biology Year: 2021 Document Type: Article