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A Meta-Analysis of Rhesus Macaques (Macaca mulatta), Cynomolgus Macaques (Macaca fascicularis), African green monkeys (Chlorocebus aethiops), and Ferrets (Mustela putorius furo) as Large Animal Models for COVID-19.
Witt, Alexandra N; Green, Rachel D; Winterborn, Andrew N.
  • Witt AN; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
  • Green RD; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
  • Winterborn AN; Office of the University Veterinarian, Queen's University, Kingston, Ontario, Canada.
Comp Med ; 71(5): 433-441, 2021 10 01.
Article in English | MEDLINE | ID: covidwho-1444659
ABSTRACT
Animal models are at the forefront of biomedical research for studies of viral transmission, vaccines, and pathogenesis, yet the need for an ideal large animal model for COVID-19 remains. We used a meta-analysis to evaluate published data relevant to this need. Our literature survey contained 22 studies with data relevant to the incidence of common COVID-19 symptoms in rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), African green monkeys (Chlorocebus aethiops), and ferrets (Mustela putorius furo). Rhesus macaques had leukocytosis on Day 1 after inoculation and pneumonia on Days 7 and 14 after inoculation, in frequencies that were similar enough to humans to reject the null hypothesis of a Fisher exact test. However, the differences in overall presentation of disease were too different from that of humans to successfully identify any of these 4 species as an ideal large animal of COVID-19. The greatest limitation to the current study is a lack of standardization in experimentation and reporting. To expand our understanding of the pathology of COVID-19 and evalu- ate vaccine immunogenicity, we must extend the unprecedented collaboration that has arisen in the study of COVID-19 to include standardization of animal-based research in an effort to find the optimal animal model.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferrets / COVID-19 Type of study: Experimental Studies / Observational study / Reviews Topics: Long Covid / Vaccines Limits: Animals / Humans Language: English Journal: Comp Med Journal subject: Medicine / Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: AALAS-CM-21-000032

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferrets / COVID-19 Type of study: Experimental Studies / Observational study / Reviews Topics: Long Covid / Vaccines Limits: Animals / Humans Language: English Journal: Comp Med Journal subject: Medicine / Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: AALAS-CM-21-000032