Assessment of serum ferritin, folate, vitamin b12, c-reactive protein, d-dimer and homocysteine in patients with severe and critical covid-19 infection

ABSTRACT

Background: Corona virus disease 2019 (COVID-19) pandemic need urgent measurement and correlation of laboratory parameters in severe and non-severe cases. Serum ferritin, folic acid, vitamin B12, C-reactive protein, D-dimer and homocysteine was measured in patients who were infected with COVID-19. Aim of the Study To evaluate the usefulness of serum ferritin, folate, B12, C-reactive protein, D-dimer and homocysteine level as biomarkers for prediction of patients with severe and critical COVID-19 infection. Subject, Material, Method: A cross sectional study was conducted at AL-Kindy hospital, Baghdad, Iraq from October 2020 to December 2020. Serum ferritin, folate, Vitamin B12, C-reactive protein, homocysteine and blood D-dimer were measured in 88 patients who suffered from COVID-19 infection, 50 cases with severe infection and 38 with non-severe infection. The age range of patients between 20-59 years old. Samples were collected from AL-Kindy hospital, Baghdad. Result: Serum folic acid was significantly low in severe group than in non-severe group, while serum ferritin, CRP and blood D-dimer were high in severe group than in non-severe group. Conclusion: In this study, measurement of serum ferritin, CRP and blood D-dimer were important in follow up of patients who infected with the novel virus as the level of them were higher in severe than in non-severe cases. Folic acid has role in determining the severity of COVID-19 infection bacause level was low in patients with severe than non-severe infection.