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Deaths post COVID-19 Vaccination: An analysis per VAERS
JACCP Journal of the American College of Clinical Pharmacy ; 4(9):1223-1224, 2021.
Article in English | EMBASE | ID: covidwho-1445837
ABSTRACT

Introduction:

To stop the spread of COVID-19, Emergency Use Authorization (EUA) vaccines from Moderna and Pfizer-BioNtech were granted in December 2020. Due to the vaccines being fasttracked, the safety profiles are being closely studied, including fatal adverse drug events. Research Question or

Hypothesis:

The purpose of this study is to identify the specific patient characteristics of those who died after receiving either the Moderna or Pfizer-BioNtech COVID-19 vaccine through the Vaccine Adverse Event Reporting System (VAERS). Study

Design:

Analysis of 717 patients who died after COVID-19 vaccination in the U.S.

Methods:

Using the VAERS, data was extracted from December 2020 to February 2021 on patients that died after receiving either the Moderna or Pfizer-BioNtech vaccine. Information collected included vaccine manufacturer, patient's age, sex, state of vaccine administration, dose received, date vaccinated, date of symptoms onset, date of death, symptoms, adverse drug event (ADE) description, medication history, allergies, current medications, and illnesses. The patients were then categorized per ADEs that possibly related to death.

Results:

A total of 568 patients were included ranging from ages 23 to 108 years old, with a median age of 78.5 and mean age of 77.3. Of the patients who died, 56% were male, and 44% were female. The top three adverse effect categories were respiratory (23.8%), cardiac (21.3%), and fatigue (10.9%). The reported deaths were similar after receiving either the Moderna vaccine (51.1%) or the Pfizer-BioNtech vaccine (48.9%). Eighty percent of patients died after receiving the first dose, and 20% died after receiving the second dose.

Conclusion:

Based on the first three months of VAERS data, fatality post-vaccination presented more in male elderly patients. Respiratory and cardiac events were the most common adverse events in this study;however, these were not prominent in manufacturer data. Further investigation would be needed to establish a direct correlation between the Moderna and Pfizer-BioNtech COVID-19 vaccines and death.

Full text: Available Collection: Databases of international organizations Database: EMBASE Topics: Long Covid / Vaccines Language: English Journal: JACCP Journal of the American College of Clinical Pharmacy Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Topics: Long Covid / Vaccines Language: English Journal: JACCP Journal of the American College of Clinical Pharmacy Year: 2021 Document Type: Article