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The COVID-19 Self-Testing through Rapid Network Distribution (C-STRAND) trial: A randomized controlled trial to increase COVID-19 testing in underserved populations.
Bien-Gund, Cedric H; Shah, Jesal; Ho, Joshua I; Stephens-Shields, Alisa; Shea, Kathleen; Fishman, Jessica; Thirumurthy, Harsha; Acri, Trisha; Dugosh, Karen; Gross, Robert.
  • Bien-Gund CH; Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, USA. Electronic address: cedric.bien-gund@pennmedicine.upenn.edu.
  • Shah J; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
  • Ho JI; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
  • Stephens-Shields A; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
  • Shea K; Public Health Management Corporation, Philadelphia, USA.
  • Fishman J; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
  • Thirumurthy H; Division of Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
  • Acri T; Courage Medicine Health Center, Philadelphia, USA.
  • Dugosh K; Public Health Management Corporation, Philadelphia, USA.
  • Gross R; Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, USA; Department of Biostatistics, Epidemiology, and Informatics, University of Pe
Contemp Clin Trials ; 110: 106585, 2021 11.
Article in English | MEDLINE | ID: covidwho-1446486
ABSTRACT
Background Widely available population testing is critical to public health efforts to control the ongoing COVID-19 pandemic. However, COVID-19 testing has been low in underserved communities disproportionately affected by COVID-19. One approach to increase testing rates is through the secondary distribution of self-collection kits, where an individual distributes test kits to contacts in their social network and encourages them to self-collect test specimens. We outline a randomized clinical trial, COVID-19 Self-testing Through Rapid Network Distribution (C-STRAND), and a cohort study of individuals with COVID-19, to determine the impact of a secondary distribution strategy on COVID-19 testing among medically underserved populations. Methods The clinical trial will seek to enroll 1048 adult index participants from federally health qualified centers in Philadelphia, PA seeking COVID-19 testing. Eligible participants will be randomized 11 to receive multiple self-collection test kits or multiple referrals for standard clinic-based tests to distribute to contacts within their social network. The primary outcome will be testing among at least two network contacts at 8 weeks. Index participants and network contacts who test positive for COVID-19 from C-STRAND will be eligible to join the COVID-19 Close Contact Self-testing Study (CloseST), assessing the secondary distribution of self-collection test kits among individuals with COVID-19. The primary outcome of this cohort will be the number of close contacts who test positive at 8 weeks. Conclusion Novel strategies to promote COVID-19 testing are necessary, particularly among underserved populations most affected by COVID-19. We will determine the efficacy of a self-testing secondary distribution strategy. The results may inform efforts to increase testing rates during the current pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Language: English Journal: Contemp Clin Trials Journal subject: Medicine / Therapeutics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Language: English Journal: Contemp Clin Trials Journal subject: Medicine / Therapeutics Year: 2021 Document Type: Article