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SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France.
Roquebert, Benedicte; Haim-Boukobza, Stéphanie; Trombert-Paolantoni, Sabine; Lecorche, Emmanuel; Verdurme, Laura; Foulongne, Vincent; Burrel, Sonia; Alizon, Samuel; Sofonea, Mircea T.
  • Roquebert B; Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
  • Haim-Boukobza S; Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
  • Trombert-Paolantoni S; Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
  • Lecorche E; Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
  • Verdurme L; Laboratoire Cerba - 7-11 r de l'Équerre, Saint-Ouen-l'Aumône 95310, France.
  • Foulongne V; Laboratoire de Virologie, CHU de Montpellier - 80 av Augustin Fliche, Montpellier 34295, France.
  • Burrel S; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), AP-HP, Hôpital Pitié-Salpêtriére, Service de Virologie - 47-83 bd de l'Hôpital, Paris 75013, France.
  • Alizon S; MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France.
  • Sofonea MT; MIVEGEC, Univ. Montpellier, CNRS, IRD - 911 av Agropolis, Montpellier Cedex 5 34394, France. Electronic address: mircea.sofonea@umontpellier.fr.
Int J Infect Dis ; 113: 12-14, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1446701
Preprint
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ABSTRACT
SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the Alpha variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for Alpha and Beta/Gamma variants exhibit significantly lower cycle threshold (Ct) values.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Variants Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.09.076

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Variants Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.09.076