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A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity.
Zhu, Huanhuan; Zheng, Fang; Li, Linxuan; Jin, Yan; Luo, Yuxue; Li, Zhen; Zeng, Jingyu; Tang, Ling; Li, Zilong; Xia, Ningyu; Liu, Panhong; Han, Dan; Shan, Ying; Zhu, Xiaoying; Liu, Siyang; Xie, Rong; Chen, Yilin; Liu, Wen; Liu, Longqi; Xu, Xun; Wang, Jian; Yang, Huanming; Shen, Xia; Jin, Xin; Cheng, Fanjun.
  • Zhu H; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Zheng F; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Li L; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Jin Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Luo Y; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Li Z; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Zeng J; School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
  • Tang L; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Li Z; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Xia N; College of Innovation and Experiment, Northwest A&F University, Yangling, Shaanxi 712100, China.
  • Liu P; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Han D; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Shan Y; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Zhu X; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Liu S; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xie R; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Chen Y; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Liu W; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Liu L; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Xu X; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 510006, China.
  • Wang J; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Yang H; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Shen X; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Jin X; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
  • Cheng F; BGI-Shenzhen, Shenzhen, Guangdong 518083, China.
iScience ; 24(10): 103186, 2021 Oct 22.
Article in English | MEDLINE | ID: covidwho-1446742
ABSTRACT
The COVID-19 pandemic has caused over 220 million infections and 4.5 million deaths worldwide. Current risk factor cannot fully explain the diversity in disease severity. Here, we present a comprehensive analysis of a broad range of patients' laboratory and clinical assessments to investigate the genetic contributions to COVID-19 severity. By performing GWAS analysis, we discovered several concrete associations for laboratory traits and used Mendelian randomization (MR) analysis to further investigate the causality of traits on disease severity. Two causal traits, WBC counts and cholesterol levels, were identified based on MR study, and their functional genes are located at genes MHC complex and ApoE, respectively. Our gene-based analysis and GSEA revealed four interferon pathways, including type I interferon receptor binding and SARS coronavirus and innate immunity. We hope that our work will contribute to studying the genetic mechanisms of disease and serve as a useful reference for COVID-19 diagnosis and treatment.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.103186

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.103186