Phagocyte metabolism: neutrophils have their cake but don't eat it.

Phelan, James J; Sheedy, Frederick J

Phelan, James J; Sheedy, Frederick J.

Phelan JJ; School of Medicine, Trinity College, Dublin, Ireland.
Sheedy FJ; School of Biochemistry and Immunology, Trinity College, Dublin, Ireland. Electronic address: fsheedy@tcd.ie.

Trends Immunol ; 42(10): 846-848, 2021 10.

Article in English | MEDLINE | ID: covidwho-1446747

ABSTRACT

ABSTRACT

Selectively targeting facets of neutrophil function could benefit infectious and inflammatory diseases. Amara et al. report on a compound which blocks human neutrophil activation by activating the glycolytic enzyme phosphofructokinase, liver-type (PFKL). Altering glucose fate by modulating this key enzymatic step could dramatically alter the function and fate of phagocytes.

Subject(s)

Neutrophils; Phagocytes; Glucose; Humans; Neutrophil Activation; Phosphofructokinase-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phagocytes / Neutrophils Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.08.011

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